WDR20 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8TBZ3 |
Other Accession | NP_653175.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 62893 Da |
Antigen Region | 5-32 aa |
Gene ID | 91833 |
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Other Names | WD repeat-containing protein 20, Protein DMR, WDR20 |
Target/Specificity | This WDR20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-32 amino acids from the N-terminal region of human WDR20. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | WDR20 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WDR20 |
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Function | Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336). Regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus (PubMed:30466959). |
Cellular Location | Cytoplasm. Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a WD repeat-containing protein. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Kee, Y., et al. J. Biol. Chem. 285(15):11252-11257(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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