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PRELP Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PRELP Antibody (Center) AP6665C
    PRELP Antibody (Center) (Cat. #AP6665c) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the PRELP antibody detected PRELP protein (arrow).
    detail
  • IHC-P - PRELP Antibody (Center) AP6665C
    PRELP Antibody (Center) (Cat. #AP6665c) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PRELP Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P51888
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 43810 Da
Antigen Region 119-148 aa
Additional Information
Gene ID 5549
Other Names Prolargin, Proline-arginine-rich end leucine-rich repeat protein, PRELP, SLRR2A
Target/Specificity This PRELP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the Central region of human PRELP.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRELP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRELP
Synonyms SLRR2A
Function May anchor basement membranes to the underlying connective tissue.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Connective tissue.
Research Areas
Citations (0)
citation

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Background

PRELP is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage.

References

Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Grover, J., et al. Matrix Biol. 26(2):140-143(2007)
Johnson, J.M., et al. Mol. Vis. 12, 1057-1066 (2006)

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$ 365.00
$ 140.00
Cat# AP6665C
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