ADRA1B Antibody (Cytoplasmic Domain)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P35368 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 57kDa |
Dilution | IHC-P (6 µg/ml) |
Gene ID | 147 |
---|---|
Other Names | Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, Alpha-1B adrenoceptor, ADRA1B |
Target/Specificity | Human ADRA1B. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SLC22A3 (50%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | ADRA1B Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ADRA1B |
---|---|
Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes. |
Cellular Location | Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm Membrane, caveola. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK- mediated signaling in cardiac myocytes. signaling in cardiac myocytes Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
References
Ramarao C.S.,et al.J. Biol. Chem. 267:21936-21945(1992).
Forray C.,et al.Mol. Pharmacol. 45:703-708(1994).
Schwinn D.A.,et al.J. Pharmacol. Exp. Ther. 272:134-142(1995).
Wright C.D.,et al.Circ. Res. 103:992-1000(2008).
Wright C.D.,et al.Cell. Signal. 24:794-802(2012).
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