TGF-beta Receptor III Antibody
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q03167 |
Other Accession | NP_003234 |
Reactivity | Human |
Host | Goat |
Clonality | Polyclonal |
Isotype | Goat IgG |
Calculated MW | 93499 Da |
Gene ID | 7049 |
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Application & Usage | Western blotting (0.5-1 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes human TGF-β Receptor III. Reactivity to other species has not been tested. |
Other Names | Transforming growth factor-beta receptor type III, Transforming growth factor-beta receptor type 3, TGF-beta type III receptor, TbetaR-III; TGFR-3, TGFG3, TGFR 3 |
Target/Specificity | TGF-b Receptor III |
Antibody Form | Liquid |
Appearance | Colorless liquid |
Formulation | 100 µg (0.5 mg/ml) antigen affinity purified goat polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide. |
Handling | The antibody solution should be gently mixed before use. |
Reconstitution & Storage | -20 °C |
Background Descriptions | |
Precautions | TGF-beta Receptor III Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TGFBR3 (HGNC:11774) |
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Function | Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity). In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility (PubMed:34910520). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P26342}; Single-pass type I membrane protein. Secreted {ECO:0000250|UniProtKB:P26342}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P26342}. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix. {ECO:0000250|UniProtKB:P26342} |
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Provided below are standard protocols that you may find useful for product applications.
Background
TGF-β (Transforming growth factor-beta superfamily members are critical regulators of cell proliferation, differentiation, morphogenesis, and pathogenesis. TGF-beta receptor is a serine/threonine kinase receptor complex that consists of two distinct transmembrane proteins known as type I and type II receptors. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and thus activation of the type I receptor kinases.
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